HAVANA (Reuters) - Cuba on Tuesday said an American accused of kidnapping his two young sons in Florida and fleeing with them by boat to the communist-led island would be turned over to U.S. authorities.
The foreign ministry announced the decision in a terse statement saying Joshua Michael Hakken, a fugitive from U.S. justice, would be handed over with wife Sharyn and their children.
Hakken had surfaced in Cuba on Tuesday and was holed up with his family at the Hemingway Marina near Havana.
Reuters and other media outlets had attempted to speak with Hakken when he appeared briefly before reporters to stow away gear and secure the hatch on a small blue and white sailboat named Salty at the marina.
But Hakken, a stocky man who was bearded and wearing shorts and a dark green baseball cap, shook his head 'no' when asked if would answer any questions.
He then disappeared into a nearby building which was roped off and plainclothes security guards equipped with walkie-talkies at the marina prevented journalists from asking any further questions.
The foreign ministry said Hakken had arrived at the marina on Sunday afternoon.
A State Department official said earlier that the United States was receiving "very good cooperation from the Cuban authorities" in the Hakken case and was providing "all appropriate assistance to the family."
Washington and Havana have no extradition agreement and tensions flared between the two Cold War enemies during the Elian Gonzalez child custody battle more than a decade ago. But there were few if any parallels between the Hakken case and Gonzalez saga, which involved a boy plucked from an inner tube off Florida after his mother and others drowned while fleeing Cuba. He was ultimately returned to his father in Cuba.
Hakken, who is wanted on two counts of kidnapping and other charges including interference with child custody, is accused of breaking into his mother-in-law's home north of Tampa, Florida, last Wednesday and tying her up with zip ties. He then fled with his sons, 4-year-old Cole and 2-year-old Chase, the Hillsborough County Sheriff's Office said.
Hours later, Hakken, his wife, and the children left from a dock in Madeira Beach, Florida, aboard the Salty, their recently purchased 25-foot (7.6-meter) sailboat, investigators said.
Hakken knew long before he went to his mother-in-law's home that he and his wife had lost custody of the children, authorities said.
The boys wound up with their maternal grandmother after the Hakkens attended an "anti-government" rally in June in Louisiana, where police said they found Hakken in the family's hotel room with a gun, marijuana and knife, talking about a "journey to Armageddon," according to the Tampa Times newspaper.
Hakken was charged with marijuana possession and the boys were placed in a foster home, where Hakken later showed up armed with a gun, the Times quoted authorities as saying.
Louisiana officials then sent the boys to live in Tampa with their maternal grandmother Patricia Hauser.
Warrants issued in Hillsborough County, in addition to kidnapping and interfering with child custody, charges of child neglect, false imprisonment, burglary with battery and stealing Hauser's car.
(Additional reporting by Saundra Amrhein in Tampa; Editing by Tom Brown and Eric Walsh)
New study shows meditating before lecture leads to better gradesPublic release date: 9-Apr-2013 [ | E-mail | Share ]
Contact: Tara Laskowski tlaskows@gmu.edu 703-993-8815 George Mason University
Practicing a little Zen before class can lead to better grades, according to a new experimental study by George Mason University professor Robert Youmans and University of Illinois doctoral student Jared Ramsburg.
The pair of researchers conducted three classroom experiments at a California university to see if meditation might help students focus better and retain information. A random selection of students followed basic meditation instructions before a lecture, and the students who meditated before the lecture scored better on a quiz that followed than students who did not meditate. In one experiment, the meditation even predicted which students passed and which students failed the quiz.
The study was published last month in the journal Mindfulness.
Interestingly, the researchers also showed that the effect of the meditation was stronger in classes where more freshmen students were enrolled, showing that meditation might have a bigger effect on freshmen students. The researchers speculate that freshmen courses likely contain the types of students who stand to benefit the most from meditation training.
"One difficulty for researchers who study meditation is that the supposed benefits of meditation do not always replicate across different studies or populations, and so we have been trying to figure out why. This data from this study suggest that meditation may help students who might have trouble paying attention or focusing. Sadly, freshmen classes probably contain more of these types of students than senior courses because student populations who have difficulty self-regulating are also more likely to leave the university," says Youmans, an assistant professor of psychology.
Youmans believes that self-reflection might therefore have an important place in freshmen seminars or institutions with high attrition rates. Their study showed a significant improvement with only six minutes of written meditation exercises and the researchers believe with more extensive training and coaching that the results could improve.
"Personally, I have found meditation to be helpful for mental clarity, focus and self-discipline," says Ramsburg, lead author of the study and a practicing Buddhist. "I think that if mindfulness can improve mental clarity, focus and self-discipline, then it might be useful in a variety of settings and for a variety of goals."
Youmans also suggests that, in theory, other forms of active self-reflection such as prayer, taking long walks or even just taking the time to mindfully plan out your day in the morning could have some of the same positive effects as meditation. "Basically, becoming just a little bit more mindful about yourself and your place in the world might have a very important, practical benefit in this case, doing better in college."
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About George Mason University
George Mason University is an innovative, entrepreneurial institution with global distinction in a range of academic fields. Located in Northern Virginia near Washington, D.C., Mason provides students access to diverse cultural experiences and the most sought-after internships and employers in the country. Mason offers strong undergraduate and graduate degree programs in engineering and information technology, organizational psychology, health care and visual and performing arts. With Mason professors conducting groundbreaking research in areas such as climate change, public policy and the biosciences, George Mason University is a leading example of the modern, public university. George Mason University-Where Innovation Is Tradition.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
New study shows meditating before lecture leads to better gradesPublic release date: 9-Apr-2013 [ | E-mail | Share ]
Contact: Tara Laskowski tlaskows@gmu.edu 703-993-8815 George Mason University
Practicing a little Zen before class can lead to better grades, according to a new experimental study by George Mason University professor Robert Youmans and University of Illinois doctoral student Jared Ramsburg.
The pair of researchers conducted three classroom experiments at a California university to see if meditation might help students focus better and retain information. A random selection of students followed basic meditation instructions before a lecture, and the students who meditated before the lecture scored better on a quiz that followed than students who did not meditate. In one experiment, the meditation even predicted which students passed and which students failed the quiz.
The study was published last month in the journal Mindfulness.
Interestingly, the researchers also showed that the effect of the meditation was stronger in classes where more freshmen students were enrolled, showing that meditation might have a bigger effect on freshmen students. The researchers speculate that freshmen courses likely contain the types of students who stand to benefit the most from meditation training.
"One difficulty for researchers who study meditation is that the supposed benefits of meditation do not always replicate across different studies or populations, and so we have been trying to figure out why. This data from this study suggest that meditation may help students who might have trouble paying attention or focusing. Sadly, freshmen classes probably contain more of these types of students than senior courses because student populations who have difficulty self-regulating are also more likely to leave the university," says Youmans, an assistant professor of psychology.
Youmans believes that self-reflection might therefore have an important place in freshmen seminars or institutions with high attrition rates. Their study showed a significant improvement with only six minutes of written meditation exercises and the researchers believe with more extensive training and coaching that the results could improve.
"Personally, I have found meditation to be helpful for mental clarity, focus and self-discipline," says Ramsburg, lead author of the study and a practicing Buddhist. "I think that if mindfulness can improve mental clarity, focus and self-discipline, then it might be useful in a variety of settings and for a variety of goals."
Youmans also suggests that, in theory, other forms of active self-reflection such as prayer, taking long walks or even just taking the time to mindfully plan out your day in the morning could have some of the same positive effects as meditation. "Basically, becoming just a little bit more mindful about yourself and your place in the world might have a very important, practical benefit in this case, doing better in college."
###
About George Mason University
George Mason University is an innovative, entrepreneurial institution with global distinction in a range of academic fields. Located in Northern Virginia near Washington, D.C., Mason provides students access to diverse cultural experiences and the most sought-after internships and employers in the country. Mason offers strong undergraduate and graduate degree programs in engineering and information technology, organizational psychology, health care and visual and performing arts. With Mason professors conducting groundbreaking research in areas such as climate change, public policy and the biosciences, George Mason University is a leading example of the modern, public university. George Mason University-Where Innovation Is Tradition.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
(BPT) ? If you experience a constant ringing in your ears that?s bothersome at best and debilitating at worst, you are far from alone. Tinnitus affects roughly one in five Americans and about 16 million people have serious tinnitus that requires medical attention. It?s also the most common disability for military veterans, since it can be caused by extended exposure to loud noise.
While tinnitus is a common condition, it?s one that can affect each person differently. While the general description involves a ringing in the ears audible only to the person with tinnitus, sufferers also report hearing a hissing, buzzing, whistling, roaring or chirping sound. It also varies in severity ? merely an unwelcome distraction for some but completely debilitating for others.
Those who have tinnitus often report trouble sleeping, an inability to concentrate or complete tasks and changes in cognitive ability. If left untreated, tinnitus can lead to extreme stress for sufferers, and can present challenges both at work and at home.
No cure, but treatment available
Tinnitus is often related to hearing loss, although it can also be associated with earwax, head injuries, medications and other conditions. Much like hearing loss, there?s no known cure for tinnitus, but there are treatments available.
Counseling and sound therapy are often used to provide relief for those with tinnitus, and the hearing aid industry has also recently developed products than can help alleviate the problems caused by tinnitus. For example, Xino Tinnitus from Starkey is an innovative, nearly invisible, behind-the-ear device that provides relief for tinnitus sufferers.
The device has adjustable features designed to allow the wearer to experience a maximum level of relief, including volume and memory controls that can be controlled with the touch of a finger. The device can help offset the irritating sounds and thus many of the problems caused by tinnitus. This device can also be used as a hearing aid for tinnitus sufferers who also have a hearing loss and could benefit from amplification. More information can be found at www.starkey.com.
What to do if you think you have tinnitus
Tinnitus is a condition that can often be treated by a hearing care professional, although certain conditions might require medical treatment from a physician or ENT. A specialist can help you develop a treatment plan and determine if a tinnitus treatment device can help alleviate your symptoms.
If you?re suffering from tinnitus, the time to get help is now. While there is no cure for tinnitus, the right treatment methods can help you manage your condition and prevent it from reaching a debilitating level. Visit www.tinnitushearing.com to learn more about this condition and find a hearing care professional near you.
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Short URL: http://www.lifeandleisurenj.com/?p=5275
It is a known factthat diet and exercise?in combination with a healthy lifestyle?play a key role in losing (and keeping) weight off. Biosanes? 30/60/90 Day Challenges include the best protein shakes for weight loss, and the best fiber supplement for women and men, and they offer a healthy eating plan for women and men!? To get the most out of your diet routine try to incorporate a fun exercise like the insanely popular Zumba!
Biosanes? Lose-It 30/60/90 Day Challenges
Enjoy your choice of two meal replacement supplements per day at breakfast, lunch or dinner. We recommend supplementing your breakfast and dinner. Choose a sensible, well-balanced option for your remaining meal. Consume three (3) Optinol capsules with a full glass of water 30-minutes prior to eating 3-times daily. Add three tablespoons of Natural Magic Pure to water or juice every day, or sprinkle Natural Magic Pure on your sensible meal for additional fiber consumption and immune boosting benefits at least 3 times per day.
We recommend 8-10 glasses of water per day for optimal results and to assist your body with the increased fiber intake from our products.
Burning Extra Calories? If you?re stepping up the workouts or simply wanting to boost your metabolism by consuming snacks between meals, simply consume one half to one full serving of The Magic Cookie? or our food replacement drinks, Lose-It Advantage,? between meals once or twice daily.? For meal ideas just check out our recipe section for ideas.
Why Zumba?
According to a recent CNN article, people are seeing drastic and amazing results by taking Zumba classes. Ashlee Tomsche takes classes five to six days a week and has dropped 123 pounds!
Benefits of Zumba
1. Say ?Burn Baby, Burn? to Calories ? The average number of calories burned during Zumba ranges anywhere from 817 to 1,050 per hour.
2. Total Body Toning ? During a Zumba class, you engage a ton of muscles and incorporate traditional fitness moves like squats and lunges into your exercise (most of the time without you realizing)
3. It Keeps You Coming Back ? Zumba is so enjoyable you actually want to keep coming back.
4. It Works for All Ages ? Zumba has a kids? program called Zumbatonic, designed to teach young dancers ages four to 12 about why it?s good to be active and healthy. There are often seniors in classes who top out at even 86!
5. Get Stress Release ? Give your mind a break from worrying about the day-to-day grind, or other more stressful life situations.
6. Can Be Adapted for Any Fitness Level ? Whether you?re just starting out with an exercise program or you?re an old pro, you can still make Zumba be an effective and challenging workout.
7. It Goes by Fast ? Class-goers swear you won?t even notice an hour has gone by. How many weight lifters can say that?
8. It?s Social! ? Regularly attending Zumba classes is a great way to meet people. Trainers often host ?Zumba parties? for corporate challenges, bachelorette parties and more.
9. Gives You More Awareness of Your Body ? Oh, you?ll be sore?in places you didn?t even know existed.
10. You Can Always Find A Class ? If you log on to the website you can find classes by zip code. Somewhere no classes are offered?? There are DVDs available to help you keep your routine going strong.
11. It Makes People Happy ? Zumba puts participants into an endorphin-release zone. Get ready to feel amazing!
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If you liked this article, also check out:
- How Yoga Best Benefits You
- The Importance of Positive Thinking
- Healthy Diets for Losing Weight: the Power of Protein
WASHINGTON (AP) ? Talk about a comeback: A treatment pulled off the market 30 years ago has won Food and Drug Administration approval again as the only drug specifically designated to treat morning sickness.
That long-ago safety scare, prompted by hundreds of lawsuits claiming birth defects, proved to be a false alarm.
Monday's FDA decision means a new version of the pill once called Bendectin is set to return to U.S. pharmacies under a different name ? Diclegis ? as a safe and effective treatment for this pregnancy rite of passage.
In the intervening decades, the treatment is widely believed to have undergone more scrutiny for safety than any other drug used during pregnancy.
"There's been a lot of buzz about this. Nothing better has come along" to treat morning sickness in those 30 years, said Dr. Edward McCabe, medical director for the March of Dimes, who welcomed the step.
"We know safety-wise, there's zero question," said Dr. Gary Hankins of the University of Texas Medical Branch in Galveston, who headed one of the company-financed studies of Diclegis that led to its approval.
U.S. sales of Diclegis are expected to begin in early June, according to Canada-based manufacturer Duchesnay Inc. The company has long sold a generic version of the pill in Canada under yet another name, Diclectin.
For all the names, the main ingredients are the same: Vitamin B6 plus the over-the-counter antihistamine doxylamine, found in the sleep aid Unisom. U.S. obstetricians have long told nauseated pregnant women how to mix up the right dose themselves.
In fact, in 2004 the American College of Obstetricians and Gynecologists issued guidelines calling the combination a first-line therapy.
The difference that prescription-only Diclegis would offer: Combining both ingredients with a delayed-release coating designed to help women take a daily dose before their nausea sets in.
The return of an FDA-cleared treatment is needed, said ACOG spokesman Dr. Jeffrey Ecker, an obstetrician at Massachusetts General Hospital who wasn't involved in the study of Diclegis.
"It's not magic," Ecker cautioned, saying few women see their symptoms completely disappear with the medication. "But for some it allows them to be much more functional."
In Hankins' study, about 260 U.S. women with morning sickness were given either Diclegis or a dummy pill for two weeks. The Diclegis users missed on average 1 1/2 fewer days of work than their counterparts.
Duchesnay wouldn't reveal a U.S. price.
About three-quarters of women experience at least some nausea and vomiting with the hormonal surges of early pregnancy. Although it often occurs upon waking, some women have trouble all day. It usually ends by the second trimester.
About 1 percent of women undergo dangerously severe vomiting called hyperemesis gravidarum, the condition that made headlines last December when in Britain, Prince William's wife Kate was briefly hospitalized.
An initial version of Bendectin began selling in 1956, and 33 million women around the world were estimated to have taken it before the lawsuits began. At the time, the FDA continued to call the drug safe; appeals courts ruled in favor of Bendectin maker Merrell Dow Pharmaceuticals; and eventually a U.S. Supreme Court decision would render continuing suits unlikely. But Merrell Dow declared the litigation cost too high, and quit making Bendectin in 1983.
What happened? The government estimates 1 in 33 babies are born with birth defects regardless of medication use during pregnancy, and studies eventually concluded that Bendectin didn't increase that baseline risk. McCabe of the March of Dimes says it's important to recognize that when a drug is widely used in pregnancy, some babies will be born with birth defects that are a coincidence.
Doctors advise trying some other steps before turning to medication for morning sickness: Eat protein snacks before bed. Nibble crackers or sip ginger ale before getting out of bed. Eat frequent small meals. Avoid nausea-triggering odors.
When that doesn't work, Ecker says vitamin B6 alone helps some women. His next step is the B6-and-antihistamine combination that will form Diclegis. A next-step option includes the drug Zofran, normally used to treat nausea from cancer therapy.
Hi everyone! I'm Dr. Paul Kochoa. I'm a physiotherapist that specializes in the evaluation and treatment of orthopedic musculoskeletal injuries, golf-related injuries, and sports injuries.
I'm an APTA board-certified orthopedic clinical specialist and a Titleist Performance Institute certified golf medical professional. Currently, I practice at Professional Physical Therapy and Training, located in the Madison and Summit, New Jersey YMCAs where I utilizee manual therapy interventions such as the Graston Technique, Kinesiotaping, and joint mobilizations to treat my clients. I received my doctorate of physical therapy from Mercy College and a BS in exercise physiology from Rutgers University. Have questions for me? I'm here for the next hour?ask away!
Have an expert you'd like to see participate? Email us.
Along with its new smaller (and cheaper) 4K TVs, Sony has announced its FMP-X1 4K media player and 4K video distribution service. Plans for both were first revealed at CES, however the official press release (included after the break) provides the full details, that it will be $699 and arrive preloaded with 10 4K films and shorts when it ships this summer. Starting in the fall, the video service will launch, with "fee-based" access to Sony's library of movies. Sony also revealed that it has started adding to the 4K movie collections for the buyers of its $25k 84-inch Ultra HDTV, delivering Lawrence of Arabia. Those buyers will be able to swap their current player for the FMP-X1 when the 4K distribution network launches in the fall. The "mastered in 4K" (but delivered in 1080p) Blu-ray discs are still part of the plan as well, and buyers of the new TVs can expect Spiderman, Ghostbusters and Angels & Demons as pack-ins.
Apr. 7, 2013 ? A new study has found that pollution from fine particles in the air -- mainly the result of burning coal or volcanic eruptions -- can shade corals from sunlight and cool the surrounding water resulting in reduced growth rates.
Although coral reefs grow under the sea it seems that they have been responding to changes in the concentration of particulate pollution in the atmosphere, according to a paper published in the journal Nature Geoscience bya team of climate scientists and coral ecologists from the UK, Australia and Panama. Corals are colonies of simple animal cells but most rely on photosynthetic algae for their energy and nutrients.
Lead author Lester Kwiatkowski, a PhD student from Mathematics at the University of Exeter, said: "Coral reefs are the most diverse of all ocean ecosystems with up to 25% of ocean species depending on them for food and shelter. They are believed to be vulnerable to climate change and ocean acidification, but ours is the first study to show a clear link between coral growth and the concentration of particulate pollution in the atmosphere."
Dr Paul Halloran of the Met Office Hadley Centre explained: "Particulate pollution or 'aerosols' reflect incoming sunlight and make clouds brighter. This can reduce the light available for coral photosynthesis, as well as the temperature of surrounding waters. Together these factors are shown to slow down coral growth."
The authors used a combination of records retrieved from within the coral skeletons, observations from ships, climate model simulations and statistical modelling. Their analysis shows that coral growth rates in the Caribbean were affected by volcanic aerosol emissions in the early 20th century and by aerosol emissions caused by humans in the later 20th century.
The researchers hope that this work will lead to a better understanding of how coral growth may change in the future, taking into account not just future carbon dioxide levels, but also localised sources of aerosols such as industry or farming.
Professor Peter Mumby of the University of Queensland put the study in the context of global environmental change: "Our study suggests that coral ecosystems are likely to be sensitive to not only the future global atmospheric carbon dioxide concentration but also the regional aerosol emissions associated with industrialisation and decarbonisation."
The study was financially supported by a NERC grant, the University of Exeter and the EU FORCE project.
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The above story is reprinted from materials provided by University of Exeter.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Lester Kwiatkowski, Peter M. Cox, Theo Economou, Paul R. Halloran, Peter J. Mumby, Ben B. B. Booth, Jessica Carilli, Hector M. Guzman. Caribbean coral growth influenced by anthropogenic aerosol emissions. Nature Geoscience, 2013; DOI: 10.1038/ngeo1780
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
TOPEKA, Kan. (AP) ? Kansas legislators gave final passage to a sweeping anti-abortion measure Friday night, sending Gov. Sam Brownback a bill that declares life begins "at fertilization" while blocking tax breaks for abortion providers and banning abortions performed solely because of the baby's sex.
The House voted 90-30 for a compromise version of the bill reconciling differences between the two chambers, only hours after the Senate approved it, 28-10. The Republican governor is a strong abortion opponent, and supporters of the measure expect him to sign it into law so that the new restrictions take effect July 1.
In addition to the bans on tax breaks and sex-selection abortions, the bill prohibits abortion providers from being involved in public school sex education classes and spells out in more detail what information doctors must provide to patients seeking abortions.
The measure's language that life begins "at fertilization" had some abortion-rights supporters worrying that it could be used to legally harass providers. Abortion opponents call it a statement of principle and not an outright ban on terminating pregnancies.
"The human is a magnificent piece of work at all stages of development, wondrous in every regard, from the microscopic until full development," said Sen. Steve Fitzgerald, a Leavenworth Republican who supported the bill.
Abortion opponents argue the full measure lessens the state's entanglement with terminating pregnancies, but abortion-rights advocates say it threatens access to abortion services.
The declaration that life begins at fertilization is embodied in "personhood" measures in other states. Such measures are aimed at revising their constitutions to ban all abortions, and none have been enacted, though North Dakota voters will have one on the ballot in 2014.
But Kansas lawmakers aren't trying to change the state constitution, and the measure notes that any rights suggested by the language are limited by decisions of the U.S. Supreme Court. It declared in its historic Roe v. Wade decision in 1973 that women have a right to obtain abortions in some circumstances, and has upheld that decision while allowing increasing restrictions by states.
Thirteen states, including Missouri, have such language in their laws, according to the National Right to Life Committee.
Sen. David Haley, a Kansas Democrat who opposed the bill, zeroed in on the statement, saying that supporters of the bill were pursuing a "Taliban-esque" course of letting religious views dictate policy limiting women's ability to make decisions about health care and whether they'll have children.
And in the House, Rep. John Wilson, a Lawrence Democrat, complained that the bill was "about politics, not medicine."
"It's the very definition of government intrusion in a woman's personal medical decisions," he said.
Brownback has signed multiple anti-abortion measures into law, and the number of pregnancies terminated in the state has declined 11 percent since he took office in January 2011.
The governor said he still has to review this year's bill thoroughly but added, "I am pro-life."
This year's legislation is less restrictive than a new North Dakota law that bans abortions as early as the sixth week of pregnancy and a new Arkansas law prohibiting most abortions after the 12th week. But many abortion opponents still see it as a significant step.
"There is a clear statement from Kansas with respect to the judgment on the inherent value of human life," said Senate Public Health and Welfare Committee Chairwoman Mary Pilcher-Cook, a Shawnee Republican and leading advocate for the measure.
The bill passed despite any solid data on how many sex-selection abortions are performed in Kansas. A 2008 study by two Columbia University economists suggested the practice of aborting female fetuses ? widespread in some nations where parents traditionally prefer sons ? is done in the U.S. on a limited basis.
But legislators on both sides of the issue said the practice should be banned, however frequent it is.
The bill also would require physicians to give women information that addresses breast cancer as a potential risk of abortion. Advocates on both sides acknowledge there's medical evidence that carrying a fetus to term can lower a woman's risk for breast cancer, but doctors convened by the National Cancer Institute a decade ago concluded that abortion does not raise the risk for developing the disease.
The provisions dealing with tax breaks are designed to prevent the state from subsidizing abortions, even indirectly. For example, health care providers don't have the pay the state sales tax on items they purchase, but the bill would deny that break to abortion providers. Also, a woman could not include abortion costs if she deducts medical expenses on her income taxes.
"Every taxpayer will be able to know with certainty that their money is not being used for abortion," Pilcher-Cook said.
But Jordan Goldberg, state advocacy counsel for the New York City-based Center for Reproductive Rights, called the tax provisions "appalling and discriminatory."
"It's probably, if not definitely unconstitutional, and it's incredibly mean-spirited," she said.
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The anti-abortion legislation is HB 2253.
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Associated Press Writer Maria Fisher in Kansas City, Mo., also contributed to this report. Follow John Hanna on Twitter at www.twitter.com/apjdhanna
Apr. 5, 2013 ? The first-in-human study of the NeuroBlate? Thermal Therapy System finds that it appears to provide a new, safe and minimally invasive procedure for treating recurrent glioblastoma (GBM), a malignant type of brain tumor.
The study, which appears April 5 in the Journal of Neurosurgery online, was written by lead author Andrew Sloan, MD, Director of Brain Tumor and Neuro-Oncology Center at University Hospitals (UH) Case Medical Center and Case Comprehensive Cancer Center, who also served as co-Principal Investigator, as well as Principal Investigator Gene Barnett, MD, Director of the Brain Tumor and Neuro-Oncology Center at Cleveland Clinic and Case Comprehensive Cancer Center, and colleagues from UH, Cleveland Clinic, Cleveland Clinic Florida, University of Manitoba and Case Western Reserve University.
NeuroBlate? is a device that "cooks" brain tumors in a controlled fashion to destroy them. It uses a minimally invasive, MRI-guided laser system to coagulate, or heat and kill, brain tumors. The procedure is conducted in an MRI machine, enabling surgeons to plan, steer and see in real-time the device, the heat map of the area treated by the laser and the tumor tissue that has been coagulated.
"This technology is unique in that it allows the surgeon not only to precisely control where the treatment is delivered, but the ability to visualize the actual effect on the tissue as it is happening," said Dr. Sloan. "This enables the surgeon to adjust the treatment continuously as it is delivered, which increases precision in treating the cancer and avoiding surrounding healthy brain tissue."
The study was a Phase I clinical trial investigating the safety and performance of NeuroBlate? (formerly known as AutoLITT?), a specially-designed laser probe system. The FDA gave the system's developer Monteris Medical and the Case Comprehensive Cancer Center (comprising the UH Case Medical Center, Cleveland Clinic, and Case Western Reserve University School of Medicine), an investigatory device exemption (IDE) to study the system in patients with GBMs. The device has recently been cleared by the FDA due, in part, to the results of the study.
The paper describes the treatment of the first10 patients with this technology. These patients, who had a median age of 55, had tumors which were diagnosed to be inoperable or "high risk" for open surgical resection because of their location close to vital areas in the brain, or difficult to access with conventional surgery.
"Overall the NeuroBlate? procedure was well-tolerated," said Dr. Sloan. "All 10 patients were alert and responsive within one to two hours post-operatively and nine out of the 10 patients were ambulatory within hours. Response and survival was also nearly 10 ? months, better than expected for patients with such advanced disease."
"Previous attempts using less invasive approaches such as brachytherapy and stereotactic radiosurgery have proven ineffective in recent meta-analysis and randomized trials," said Dr. Barnett. "However, unlike therapies using ionizing radiation, NeuroBlate? therapy results in tumor death at the time of the procedure. A larger national study will be developed, as a result of this initial success."
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The above story is reprinted from materials provided by University Hospitals Case Medical Center, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Andrew E. Sloan, Manmeet S. Ahluwalia, Jose Valerio-Pascua, Sunil Manjila, Mark G. Torchia, Stephen E. Jones, Jeffrey L. Sunshine, Michael Phillips, Mark A. Griswold, Mark Clampitt, Cathy Brewer, Jennifer Jochum, Mary V. McGraw, Dawn Diorio, Gail Ditz, Gene H. Barnett. Results of the NeuroBlate System first-in-humans Phase I clinical trial for recurrent glioblastoma. Journal of Neurosurgery, 2013; DOI: 10.3171/2013.1.JNS1291
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Singh, one half of the infamous Singh brothers who run Percept, the media and communications firm with fingers in the music, sports and Bollywood businesses, is a hella of a spin man. He?s shaped more than one rough cut Bollywood star, given the country its largest EDM festival and been embroiled in his fair share of controversies, so he?s probably got a story or two to sell. Except having likely had a hand in causing murmurs of what was to come from his memoirs, he?s spun the biggest con of them all: this isn?t a juicy tell all with delicious dark secrets that, holy legit lawsuit, might cause certain stars to sweat and sue him for defamation. In fact the only pulses likely to race are those of school teachers who might scowl at the liberal usage of the word fuck, written here annoyingly enough as f?@k, and upon whose many applications the entire crux of this books rests.
It?s self help masqueraded as a memoir, with bits and bobs ham fistedly pulled from Singh?s favourite enlightenment authors, where The Power of Now, The Monk Who Sold His Ferrari and The Secret is spliced with Osho and Deepak Chopra and the word f?@k because well, fuck knows. Cavalier as Singh is about his tryst with fame and glitz, even he?s canny enough to know that when your entire career is built on maintaining relationships with the powers that be, it doesn?t pay to name names. Instead to give his readers some amount of bang for their vastly overpaid 195 bucks, Singh dispenses his remedies for living well. Create a fuck it list (?it just like a bucket list, but with a cooler name?), trust your gut, apply yourself, do what you love, channel your chi by saying chi f?@k a lot, know who you want to be, do what you want, look after yourself and oh, don?t worry so much. Why?
Because ?Worrying is like riding a tiger. If you can stay on top of it, you will enjoy the ride. If you get off, the tiger will eat you.? If presented with this book, may we suggest you hope choose the latter option.
Mobile ad startup Drawbridge offers technology that helps identify when multiple devices are being used by a single user ? something that's pretty appealing to advertisers, but could also have significant privacy implications. Drawbridge is announcing today that it's partnering with privacy management company TRUSTe so that people who see Drawbridge-served ads can opt out of the targeting. We hear about companies working with TRUSTe all the time ? there are enough of them that announcements can start to feel pretty ho-hum. But the Drawbridge partnership seemed worth pointing out because it's another sign that TRUSTe's AdChoices model, where consumers can opt out of data collection and targeting, is spreading to mobile. And it's also the first time that opting out has applied across multiple devices.
Corals thrive at Scott Reef. Scientists have seen some amazing recuperating powers by coral reefs that were heavily damaged.
By Douglas Main LiveScience
Coral reefs may be more independent and resilient than previously thought.
New research shows that an isolated reef off the northwest coast of Australia that was severely damaged by a period of warming in 1998 has regenerated in a very short time to become nearly as healthy as it was before. What surprises scientists, though, is that the reef regenerated by itself, found a study published Thursday?in the journal Science
Until now, scientists have thought that damaged reefs depend on new recruits from nearby reefs to quickly heal themselves, said study author James Gilmour, a researcher at the Australian Institute of Marine Science. But this study found that may not always be the case?-- at least with reefs like this one, which has good water quality and isn't heavily impacted by humans, Gilmour told OurAmazingPlanet in an email.
Hot water In 1998, unusually warm weather heated up waters off the northwest coast of Australia by about 4 degrees Fahrenheit (2 degrees Celsius) above average. These temperatures persisted for several weeks. ?
The heat led to the bleaching of the corals, in which corals kick out the tiny symbiotic algae housed within them that provide corals food. If the water's temperature quickly returns to normal, the coral can recover. But often, it dies, becoming a white skeleton of its former self.
The 1998 event killed 70 percent to 90 percent of corals in various parts of the reef, and the number of coral embryos collected by researchers monitoring the reef dropped to almost zero. Gilmour said this shows that the remaining corals weren't reproducing and that there weren't any coral embryos washing in from surrounding reefs. Recovery was expected to take many decades, Gilmour said. [Stressed Coral: Photos of Great Barrier Reef]
Recovery At first, the reef grew slowly, mostly through the enlargement of existing coral colonies. But to really recover, the coral needs to sexually reproduce, creating sperm and egg that form embryos that then land on the ocean floor and grow into adult corals, if all goes well. These larvae can survive for hundreds of miles, swept along by ocean currents, and colonize new areas under the right circumstances.
Larvae floating in from other reefs could have helped the reef, had it not been so isolated.
But amazingly, after about six years, the surviving corals matured and began to reproduce, creating even more new colonies than before the bleaching. "They recovered, and the larvae they produced settled and survived, at much higher rates than is often reported," Gilmour said. By 2012, the reef was basically back to its old self.
The study suggests that, when it comes to reefs, being isolated from human activity may trump being connected to other reefs. Why? Human activities can hurt reefs in a number of ways. Overfishing, for example, removes fish that keep algae from choking out and outcompeting corals, and sediment and pathogens in runoff water can lead to coral diseases and death.
But the results also mean that local decisions about fishing and other issues can help preserve reefs, which are threatened by global warming. "Managing local conditions is a tangible way to maximize the resilience of coral reefs while the more difficult problem of addressing the causes of climate change are resolved," Gilmour said.
Email Douglas Mainor follow him @Douglas_Main. Follow us?@OAPlanet, Facebook?or? Google+.Original article on LiveScience's OurAmazingPlanet.
Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
So after many months of hemming and hawing about creating a new product, thinking about if I had the energy, or if I should just focus on my existing product that my ex-husband and I developed and have been success at I have decided to go ahead and just do it! ?And I thought I would show everyone how I am going to develop a product that I will be able to conscientiously sell for over $1,500. ?I am sure that other online marketing wouldn?t want me to lay it all out like this, but I have never been one to hold back information?or follow rules for that matter
So my plan is that I will show you how I create this brand new product. ?I have found that when I create the sales page and sales funnel first, it gives me a better idea of how I can better develop the product. ?So, normally someone might create the product first and then the sales page, but I am going to go the opposite way. ?I find that when I write sales copy for a sales page I think of other create things I can add to a product that would add a lot of value. ?Wit
With that said, my first video diary is of me setting up the sales funnel. ?I encourage you to subscribe to my youtube Channel here http://www.youtube.com/emilygrahamfb to you get the updates when I post my next video.
You're biased about sports. It's fine, we all are. It's part of the allure. But it's just as fun breaking it down to see exactly how we're biased. Yahoo gave Facebook Data access to its more than 60,000 brackets filled out by Facebook users, which Facebook has in turn made into some awesome visuals showing exactly who's the most biased, and in what ways. More »
This guest article from YourTango was written by?Harville Hendrix & Helen LaKelly Hunt.
Falling in love can be amazing! The excitement of meeting someone new brings out the best in all of us; the journey ahead feels like an open road full of possibility.
But then something happens: Either the relationship starts to feel stale, or perhaps money issues, kids, or trying to figure out a comfortable work-life balance comes into play. Whatever the cause, the initial spark dims or goes out altogether, and the future of your relationship becomes a long and winding road, full of pit stops and flat tires.
Well, don?t worry because this happens to everyone. All it means is that it?s time for a tune-up.
You see, we spend a lot of time and energy finding our perfect mates. By the time we say ?I do,? we assume (and fervently hope) that the work is over. The idea of having to spend time working on your marriage may seem strange or even depressing, but it?s worth it! Even if it feels like your whole marriage needs an overhaul, deepening your relationship doesn?t have to be a grueling process. With the right tools, the suffering can end.
One of the best ways to help your marriage is to ensure you?re thinking about it the right way. After working with thousands of couples ? and on our own marriage ? we?ve distilled some essential truths that help couples keep their relationships fresh as they navigate the life-long experience of growing real love:
1. Conflict is growth trying to happen.
Most people believe that if you?re having problems in your marriage, you?re with the wrong person. So, when conflict gets heated and gnarly, they wonder if it?s time to bail ? and it?s not! Rather, if you?re willing to work with the conflict, there is something wonderful and amazing waiting for you right around the corner. The key is learning how to work with conflict creatively ? in ways that help both you and your partner grow. Plus, just changing your perspective so that you view conflict as an opportunity, an indicator that it?s time to grow, can help ease the troubles you ?re having.
2. It?s not him; it?s you.
Ninety percent of the upset you feel with your partner comes from your past. It?s true! So, stop blaming your partner. We know that it?s hard to do ? especially when you feel miserable and it seems as though the source of your misery is, well, that annoying person you?re married to. But here?s the thing: We fall head over heels in love with someone who is similar to our parents, which is a mysterious design that holds the potential for deep, abiding connection ? once you get past all the squabbling. So, the next time you feel your blood boiling, remind yourself: This feeling has more to do with my past than my partner!
3. A laugh a day keeps the divorce lawyer away.
Sometimes we?re so busy working on our relationships that we actually forget to enjoy them. And what?s the point of doing all of that work if you?re not having fun with your partner? Using humor and joy is critical to a couple?s happiness together. Now, this doesn?t mean you get to dust off your passive-aggressive tendencies and use ?humor? to zing your partner with little digs or critiques. What it means is that you have our permission to go out and have fun. So, create fun times together by mixing things up a little. Try dance lessons, improv, a cooking class.
When we decided to bring the fun back into our relationship, we cooked a whole meal together wearing Groucho Marx glasses. Of course we felt silly ? and that was the whole point!
4. Want to spice up your relationship? Ditch all negativity!
Why are we so inclined to focus on what?s bad instead of what?s good? Every relationship (including ours, once upon a time) contains at least some negativity, and the amount of negativity in a relationship is directly proportional to the amount of trouble it?s in. Negativity includes any/all words, tone of voice, facial expressions and/or behavior your partner says feels negative to him/her. And yes, rolling your eyes counts.
You see, negativity is like rat poison; nothing can grow in it! So, if you want your relationship to grow, you?ve got to get rid of all negativity. Yes, all of it. We finally did, and in fact, our zero tolerance policy is the single most effective strategy we?ve used to create real love.
These truths can help you become better partners for each other, and to create a marriage full of real, lasting love and a blissful connection.
?
Harville Hendrix, Ph.D. and Helen LaKelly Hunt, Ph.D. are bestselling authors and creators of Imago Relationship Therapy, which is practiced by over 2,000 therapists around the world. Partners in life and work, their newest book Making Marriage Simple distills what they have learned into ten essential and provocative truths about marriage.
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More marriage advice from YourTango:
Contributed by YourTango.com, an online magazine dedicated to love, life and relationships. From dating to marriage, parenting to empty-nest, relationship challenges to relationship success, YourTango is at the center of the conversations that are closest to our over 7 million readers' hearts. With daily contributions from our Experts, we have a little something for everyone looking to create healthier lives. We're excited to offer our contributions to the PsychCentral community, and invite you to visit us on YourTango.com.
Like this author? Catch up on other posts by YourTango Experts (or subscribe to their feed).
????Last reviewed: By John M. Grohol, Psy.D. on 2 Apr 2013 ????Published on PsychCentral.com. All rights reserved.
APA Reference Experts, Y. (2013). Relationship Tune-Up: How to Stop Your Marriage from Falling Apart. Psych Central. Retrieved on April 4, 2013, from http://psychcentral.com/blog/archives/2013/04/03/relationship-tune-up-how-to-stop-your-marriage-from-falling-apart/
Editor's note: Yahoo News asked young libertarian-minded voters to share why they're drawn to the either the Libertarian Party or to libertarian political principles in general. Here's one first-person account we received this week.
FIRST PERSON | I was raised as a typical Republican conservative might be: with a focus on conservative family values. I'm now 26 and I've spent most of my time in Georgia. (I currently reside in Augusta). I quickly realized that no political party could properly espouse my individual views, since, as we all learned in entry level political science, the goal of a political party is to win elections.
Imagine a man almost $57,000 in debt. You walk up to this man an ask him what his plan to get out of debt is. He stands there for a minute, shrugs his shoulders, sticks his hands in his pockets, and says he's going to cut his $4,300 yearly deficit some in order to reduce the problem. That's right: he's going to slow down (slightly) the rate at which he descends deeper into debt!
Now multiply this man by 300 million, and you have a nearly $17 trillion debt with a $1.3 trillion deficit. Sound familiar? This is where the United States currently stands (information publicly available) as of 2013. (2011 deficit data and March 30 debt data).
When I did this math for myself at North Georgia College ad State University in Dahlonega, I became a firm fiscal conservative. As I plunged into early adulthood, I realized that my status as a debt-free citizen helped me to avoid the financial pitfalls of my parents and many of the previous generation. I believed that the government should be equally frugal with its monetary policy, and this placed me firmly in the libertarian camp. I've identified as libertarian for approximately eight years.
Libertarians don't espouse a large-party platform, nor do they have a coherent, party-like ideology. The only central tenets are less government and more individual freedom. When I realized that my desire to see our government make itself debt-free would require vastly smaller spending and more individual responsibility, I realized that my views were libertarian ones.
The issue I have with the overly broad Republican and Democratic parties is that, in their attempt to win elections, they attempt to satisfy everyone by putting politicians into power that will expand all forms of spending including defense and social programs. This runs counter to my vision of a debt-free nation, which I believe is the correct path to prosperity.
Agios research demonstrates the effects of mutant IDH1 and IDH2 inhibitors in primary tumor modelsPublic release date: 4-Apr-2013 [ | E-mail | Share ]
Contact: Dan Budwick dan@purecommunicationsinc.com 973-271-6085 Pure Communications Inc.
IDH1 and IDH2 mutant inhibitors reverse differentiation blocks in patient-derived tumor samples
Cambridge, Mass. April 4, 2013 Agios Pharmaceuticals, Inc., the leading biopharmaceutical company focused on discovering and developing novel drugs in the fields of cancer metabolism and rare metabolic genetic diseases, announced today the publication of two articles in the journal Science by Agios scientists and their collaborators demonstrating the effects of the company's small molecule isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) mutant specific inhibitors in primary human tumor models. These data add to a growing body of scientific research demonstrating the significant promise of targeting mutant IDH1 and IDH2 enzymes as novel approaches to treating cancer.
"These papers represent the first publications to show the effects of inhibiting mutant IDH1 and IDH2 enzymes in patient-derived tumor samples, extending Agios' record of scientific leadership in cancer metabolism," said David Schenkein, M.D., chief executive officer at Agios. "While IDH mutations are genetically validated cancer targets, these findings provide further preclinical support that these mutations are driving disease, and appropriately targeted therapeutics can reverse the effects. Our IDH programs continue to produce promising results, and we are excited to advance toward clinical studies that will bring a potentially transformative treatment option to patients."
Tumors carrying IDH mutations are known to produce high levels of 2-HG, as shown originally by Agios scientists in Nature in 2009. In the first Science article, titled "Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation," Agios scientists show that cancer-associated IDH mutations may cause a block in cellular differentiation to promote tumorigenesis. To elucidate the relationship between mutant enzyme activity, 2-HG levels and oncogenic state, Agios developed a mutant-selective IDH2 inhibitor. Primary samples of acute myeloid leukemia (AML) cells were derived from four patients with AML carrying the IDH2 mutation. Upon treatment with the inhibitor, differentiation of blast (leukemic) cells was observed. In a separate experiment in TF-1 cells, the inhibitor was able to restore the ability of the cells to differentiate upon stimulation with erythropoeitin. Each of these observations was correlated with dose-dependent reductions in the oncometabolite 2-HG, which is thought to block differentiation in leukemia cells harboring IDH mutations.
In the second article, "An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells," Agios researchers, Ingo K. Mellinghoff, M.D., of Memorial Sloan-Kettering Cancer Center, and colleagues from several institutions report that a selective mutant IDH1 inhibitor discovered at Agios blocked the ability of mutant IDH1 to produce 2-HG in an in vivo primary xenograft model, impairing the growth of patient-derived IDH1-mutant glioma (brain cancer) cells. Furthermore, reduction of 2-HG to near basal levels induced expression of genes involved in both astroctyic and oligodendrocyte differentiation.
These data suggest that targeted therapy with IDH mutant inhibitors could induce tumor cell differentiation and support clinical study of IDH1 and IDH2 mutant targeted agents for the treatment of AML and other cancers. Both articles were published online in the journal Science on April 4, 2013.
###
About IDH Mutations
The connection between cancer and metabolism has been the central focus of scientists at Agios, who were the first to identify the neo-activity of IDH1 mutations to produce the oncometabolite 2-HG in research published in Nature in 2009. These insights revealed the potential of IDH1 mutations as a novel therapeutic target in cancer. The IDH1 gene mutation was initially discovered in brain cancers in 2008 by researchers at Johns Hopkins. More recently, mutations in both IDH1 and IDH2 have been linked to AML, one of the most common types of leukemia in adults, as well as several other cancers.
About Agios Pharmaceuticals, Inc.
Agios is the leading biopharmaceutical company focused on discovering and developing novel drugs in the fields of cancer metabolism and rare metabolic genetic diseases. In addition to an active research and discovery pipeline across both therapeutic areas, Agios has multiple first-in-class programs in cancer metabolism and inborn errors of metabolism advancing toward the clinic. All Agios programs focus on genetically identified patient populations leveraging our knowledge of metabolism, biology and genomics. For more information, please visit our website at http://www.agios.com.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Agios research demonstrates the effects of mutant IDH1 and IDH2 inhibitors in primary tumor modelsPublic release date: 4-Apr-2013 [ | E-mail | Share ]
Contact: Dan Budwick dan@purecommunicationsinc.com 973-271-6085 Pure Communications Inc.
IDH1 and IDH2 mutant inhibitors reverse differentiation blocks in patient-derived tumor samples
Cambridge, Mass. April 4, 2013 Agios Pharmaceuticals, Inc., the leading biopharmaceutical company focused on discovering and developing novel drugs in the fields of cancer metabolism and rare metabolic genetic diseases, announced today the publication of two articles in the journal Science by Agios scientists and their collaborators demonstrating the effects of the company's small molecule isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) mutant specific inhibitors in primary human tumor models. These data add to a growing body of scientific research demonstrating the significant promise of targeting mutant IDH1 and IDH2 enzymes as novel approaches to treating cancer.
"These papers represent the first publications to show the effects of inhibiting mutant IDH1 and IDH2 enzymes in patient-derived tumor samples, extending Agios' record of scientific leadership in cancer metabolism," said David Schenkein, M.D., chief executive officer at Agios. "While IDH mutations are genetically validated cancer targets, these findings provide further preclinical support that these mutations are driving disease, and appropriately targeted therapeutics can reverse the effects. Our IDH programs continue to produce promising results, and we are excited to advance toward clinical studies that will bring a potentially transformative treatment option to patients."
Tumors carrying IDH mutations are known to produce high levels of 2-HG, as shown originally by Agios scientists in Nature in 2009. In the first Science article, titled "Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation," Agios scientists show that cancer-associated IDH mutations may cause a block in cellular differentiation to promote tumorigenesis. To elucidate the relationship between mutant enzyme activity, 2-HG levels and oncogenic state, Agios developed a mutant-selective IDH2 inhibitor. Primary samples of acute myeloid leukemia (AML) cells were derived from four patients with AML carrying the IDH2 mutation. Upon treatment with the inhibitor, differentiation of blast (leukemic) cells was observed. In a separate experiment in TF-1 cells, the inhibitor was able to restore the ability of the cells to differentiate upon stimulation with erythropoeitin. Each of these observations was correlated with dose-dependent reductions in the oncometabolite 2-HG, which is thought to block differentiation in leukemia cells harboring IDH mutations.
In the second article, "An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells," Agios researchers, Ingo K. Mellinghoff, M.D., of Memorial Sloan-Kettering Cancer Center, and colleagues from several institutions report that a selective mutant IDH1 inhibitor discovered at Agios blocked the ability of mutant IDH1 to produce 2-HG in an in vivo primary xenograft model, impairing the growth of patient-derived IDH1-mutant glioma (brain cancer) cells. Furthermore, reduction of 2-HG to near basal levels induced expression of genes involved in both astroctyic and oligodendrocyte differentiation.
These data suggest that targeted therapy with IDH mutant inhibitors could induce tumor cell differentiation and support clinical study of IDH1 and IDH2 mutant targeted agents for the treatment of AML and other cancers. Both articles were published online in the journal Science on April 4, 2013.
###
About IDH Mutations
The connection between cancer and metabolism has been the central focus of scientists at Agios, who were the first to identify the neo-activity of IDH1 mutations to produce the oncometabolite 2-HG in research published in Nature in 2009. These insights revealed the potential of IDH1 mutations as a novel therapeutic target in cancer. The IDH1 gene mutation was initially discovered in brain cancers in 2008 by researchers at Johns Hopkins. More recently, mutations in both IDH1 and IDH2 have been linked to AML, one of the most common types of leukemia in adults, as well as several other cancers.
About Agios Pharmaceuticals, Inc.
Agios is the leading biopharmaceutical company focused on discovering and developing novel drugs in the fields of cancer metabolism and rare metabolic genetic diseases. In addition to an active research and discovery pipeline across both therapeutic areas, Agios has multiple first-in-class programs in cancer metabolism and inborn errors of metabolism advancing toward the clinic. All Agios programs focus on genetically identified patient populations leveraging our knowledge of metabolism, biology and genomics. For more information, please visit our website at http://www.agios.com.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 9-Apr-2013
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Hi everyone! I'm Dr. Paul Kochoa. I'm a physiotherapist that specializes in the evaluation and treatment of orthopedic musculoskeletal injuries, golf-related injuries, and sports injuries. 
Should you buy Shailendra Singh?s F?@k Knows?
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This guest article from YourTango was written by?Harville Hendrix & Helen LaKelly Hunt.